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Lorus Therapeutics Announces Positive Results from Its Small Molecule Antimicrobial Program
Potent Antibacterial Activity of LOR-220 Includes Drug-Resistant "Superbugs"
TORONTO, ONTARIO--(March 27, 2012) - Lorus Therapeutics Inc. (TSX:LOR) ("Lorus"), a biopharmaceutical company specializing in the discovery, research and development of pharmaceutical products and technologies for the management of cancer, today announced promising results obtained from preclinical studies on its lead antimicrobial small molecule compound LOR-220.
The studies examined the antibacterial activity of LOR-220 against drug sensitive and drug resistant bacteria that had been isolated from patients with bacteremia and other bacterial infections. LOR-220 showed potent antibacterial activity against a panel of 330 clinical isolates of bacteria, including Streptococcus pneumoniae, methicillin-resistant Staphylococcus aureus (MRSA), and Vancomycin-resistant enterococci (VRE) among the so-called "superbugs". In addition, LOR-220 demonstrated higher antibacterial activity than that of Vancomycin and Linezolid, both of which are antibiotics currently used to treat serious bacterial infections.
LOR-220 also significantly improved survival of mice infected with two different species of VRE, which, when left untreated, led to 100% lethality. Lorus previously reported similar effects of LOR-220 in improving survival of mice infected with an epidemic strain of MRSA.
The study was carried out for Lorus by Sichuan Industrial Institute of Antibiotics, a research and development based pharmaceutical organization.
"One of the biggest healthcare concerns world-wide is the limited number of therapeutic options available to treat emerging infections caused by multi-drug resistant bacteria such as MRSA and VRE in hospitals and communities. A significant challenge for combating these infections is finding new antimicrobials that work against novel bacterial targets, to reduce or eliminate cross-resistance to existing antibiotics. These new data, generated against hundreds of clinical isolates, provide strong support for further development of LOR-220 and validate the potential of our antimicrobial program", said Dr. Aiping Young, Lorus' President and CEO.
Lorus currently focuses on the development of novel therapies for cancer treatment and has prioritized the development of its clinical stage small molecule drug candidate LOR-253, its immunotherapeutic agent, IL-17E, and its new small molecule program, LOR-500. The Company is in discussions with potential partners to advance the development of LOR-220 as a novel, first-in-class antimicrobial for the treatment of serious infections caused by Gram-positive bacterial pathogens.
LOR-220 is a small molecule developed by Lorus that targets a class of novel bacterial proteins called kinases, which have recently emerged as critical signaling molecules in bacteria. Previous studies performed at Lorus using reference bacterial strains demonstrated activity of LOR-220 against multi-drug resistant Gram-positive bacteria such as methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), and other pathogens that are emerging as a major cause of severe infections in hospitals and communities world-wide.
Lorus is a biopharmaceutical company focused on the discovery, research and development of novel therapeutics in cancer. Lorus' goal is to capitalize on its research, preclinical, clinical and regulatory expertise by developing new drug candidates that can be used, either alone, or in combination with other drugs, to successfully manage cancer. The Company also has expertise in antimicrobial drug discovery. Lorus Therapeutics Inc. is listed on the Toronto Stock Exchange under the symbol LOR.
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